Act 5, Scene 5, Line 13-15 - Macbeth - "I have supped full with horrors. Direness, familiar to my slaughterous thoughts Cannot once start me."

Macbeth in this quote he says how he has basically seen it all, nothing can ever scare him. He feels no fear of anything anymore, Macbeth asserted that he has almost forgotten what fear was. Not even a ghost story can scare him anymore. So Macbeth's state of mind is absolutely blunt now and he is beginning to be fearless and careless about what he says. He knows or feels that his time of death is coming up.